76,512 XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 31 Jul 2024 | 11,454 | 12,745 | - | 1.7 | 19,930 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jul 2024 | 1,507 | 0 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jul 2024 | 10,548 | 1,507 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jul 2024 | 906 | 0 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 31 Jul 2024 | 1,507 | 14,252 | - | 1.7 | 2,622 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2024 | 15,000 | 28,763 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 14 Jun 2024 | 15,000 | 20,022 | - | 2.1 | 32,100 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.03 per share. | 14 Jun 2024 | 15,000 | 5,022 | - | 25.0 | 375,450 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.59 per share. | 14 Jun 2024 | 10,600 | 10,600 | - | 14.6 | 154,654 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2024 | 10,600 | 68,800 | - | - | Stock Option (Right to Buy) | |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 14 Jun 2024 | 10,600 | 0 | - | 25 | 265,000 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 24.50 per share. | 13 Jun 2024 | 6,000 | 5,602 | - | 24.5 | 147,000 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jun 2024 | 6,000 | 83,510 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 13 Jun 2024 | 6,000 | 11,602 | - | 2.1 | 12,840 | Common Stock |
| Donald J. Santel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Mark T. Iwicki | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Allison Dorval | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Joshua Resnick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Habib Joseph Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Maha Katabi | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| David S. Grayzel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 17 May 2024 | 4,000 | 9,602 | - | 2.1 | 8,560 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 4,000 | 11,324 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 21.86 per share. | 17 May 2024 | 86 | 5,602 | - | 21.9 | 1,880 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 21.07 per share. | 17 May 2024 | 3,914 | 5,688 | - | 21.1 | 82,452 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 16 May 2024 | 10,000 | 10,000 | - | 2.1 | 21,400 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2024 | 10,000 | 343,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 21.92 per share. | 16 May 2024 | 1,293 | 0 | - | 21.9 | 28,345 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 21.52 per share. | 16 May 2024 | 8,707 | 1,293 | - | 21.5 | 187,410 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Sale of securities on an exchange or to another person at price $ 21.02 per share. | 02 May 2024 | 1,981 | 0 | - | 21.0 | 41,631 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 01 May 2024 | 10,000 | 10,000 | - | 2.1 | 21,400 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 10,000 | 353,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 19.91 per share. | 01 May 2024 | 1,357 | 0 | - | 19.9 | 27,018 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 20.87 per share. | 01 May 2024 | 965 | 0 | - | 20.9 | 20,135 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 20.34 per share. | 01 May 2024 | 9,035 | 965 | - | 20.3 | 183,793 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 23.97 per share. | 17 Apr 2024 | 68 | 1,291 | - | 24.0 | 1,630 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 23.17 per share. | 17 Apr 2024 | 338 | 1,359 | - | 23.2 | 7,831 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2024 | 6,853 | 95,936 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 17 Apr 2024 | 6,853 | 8,144 | - | 2.1 | 14,665 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 22.32 per share. | 17 Apr 2024 | 6,447 | 1,697 | - | 22.3 | 143,865 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 17 Apr 2024 | 4,000 | 7,251 | - | 1.7 | 6,960 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2024 | 3,497 | 539 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2024 | 503 | 2,511 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 23.33 per share. | 17 Apr 2024 | 311 | 3,251 | - | 23.3 | 7,255 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 22.30 per share. | 17 Apr 2024 | 3,689 | 3,562 | - | 22.3 | 82,267 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 24.94 per share. | 16 Apr 2024 | 5,509 | 0 | - | 24.9 | 137,410 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 24.40 per share. | 16 Apr 2024 | 4,491 | 5,509 | - | 24.4 | 109,561 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Apr 2024 | 10,000 | 363,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 16 Apr 2024 | 10,000 | 10,000 | - | 2.1 | 21,400 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 26.77 per share. | 10 Apr 2024 | 6,729 | 2,731 | - | 26.8 | 180,139 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 10 Apr 2024 | 7,500 | 9,460 | - | 2.1 | 16,050 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2024 | 7,500 | 43,763 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 27.56 per share. | 10 Apr 2024 | 771 | 1,960 | - | 27.6 | 21,252 | Common Stock |
| David S. Grayzel | Director | Sale of securities on an exchange or to another person at price $ 28.15 per share. | 09 Apr 2024 | 11,882 | 14,502 | - | 28.1 | 334,478 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 31.23 per share. | 01 Apr 2024 | 12,495 | 1,960 | - | 31.2 | 390,208 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 01 Apr 2024 | 12,495 | 14,455 | - | 2.1 | 26,739 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2024 | 12,495 | 15,768 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 01 Apr 2024 | 10,000 | 10,000 | - | 2.1 | 21,400 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2024 | 10,000 | 373,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 31.95 per share. | 01 Apr 2024 | 1,000 | 0 | - | 32.0 | 31,950 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 31.02 per share. | 01 Apr 2024 | 2,851 | 1,000 | - | 31.0 | 88,446 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 29.90 per share. | 01 Apr 2024 | 1,647 | 3,851 | - | 29.9 | 49,238 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 28.96 per share. | 01 Apr 2024 | 4,502 | 5,498 | - | 29.0 | 130,399 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2024 | 3,325 | 25,675 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 31.98 per share. | 01 Apr 2024 | 3,325 | 1,291 | - | 32.0 | 106,317 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.61 per share. | 01 Apr 2024 | 3,325 | 4,616 | - | 10.6 | 35,278 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2024 | 5,300 | 79,400 | - | - | Stock Option (Right to Buy) | |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.59 per share. | 01 Apr 2024 | 5,300 | 5,300 | - | 14.6 | 77,327 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Sale of securities on an exchange or to another person at price $ 28.87 per share. | 01 Apr 2024 | 3,796 | 1,504 | - | 28.9 | 109,579 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 01 Apr 2024 | 1,504 | 0 | - | 30.0 | 45,118 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Mar 2024 | 9,000 | 89,510 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 28 Mar 2024 | 9,000 | 12,251 | - | 2.1 | 19,260 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 29.50 per share. | 28 Mar 2024 | 9,000 | 3,251 | - | 29.5 | 265,500 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.61 per share. | 27 Mar 2024 | 11,068 | 12,359 | - | 10.6 | 117,431 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Mar 2024 | 11,068 | 29,000 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 27.97 per share. | 27 Mar 2024 | 11,068 | 1,291 | - | 28.0 | 309,519 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.61 per share. | 25 Mar 2024 | 3,432 | 4,723 | - | 10.6 | 36,414 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2024 | 3,432 | 40,068 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 28.01 per share. | 25 Mar 2024 | 3,432 | 1,291 | - | 28.0 | 96,119 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Sale of securities on an exchange or to another person at price $ 26.46 per share. | 19 Mar 2024 | 2,764 | 0 | - | 26.5 | 73,124 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Sale of securities on an exchange or to another person at price $ 25.68 per share. | 19 Mar 2024 | 2,536 | 2,764 | - | 25.7 | 65,119 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.59 per share. | 19 Mar 2024 | 5,300 | 5,300 | - | 14.6 | 77,327 | Common Stock |
| Marinus Verwijs | CHIEF TECHNICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2024 | 5,300 | 84,700 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 18 Mar 2024 | 20,557 | 21,848 | - | 2.1 | 43,992 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2024 | 14,500 | 43,500 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2024 | 20,557 | 102,789 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 26.48 per share. | 18 Mar 2024 | 7,581 | 1,291 | - | 26.5 | 200,764 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.74 per share. | 18 Mar 2024 | 27,476 | 8,872 | - | 25.7 | 707,282 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.61 per share. | 18 Mar 2024 | 14,500 | 36,348 | - | 10.6 | 153,845 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 18 Mar 2024 | 3,000 | 10,251 | - | 2.1 | 6,420 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2024 | 3,000 | 98,510 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2024 | 4,000 | 4,036 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 26.40 per share. | 18 Mar 2024 | 613 | 3,251 | - | 26.4 | 16,185 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 25.81 per share. | 18 Mar 2024 | 6,387 | 3,864 | - | 25.8 | 164,872 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 18 Mar 2024 | 4,000 | 7,251 | - | 1.7 | 6,960 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Mar 2024 | 2,016 | 51,263 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 12 Mar 2024 | 2,051 | 4,011 | - | 2.1 | 4,389 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.05 per share. | 12 Mar 2024 | 2,051 | 1,960 | - | 25.0 | 51,370 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 12 Mar 2024 | 2,016 | 3,976 | - | 2.1 | 4,314 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.02 per share. | 12 Mar 2024 | 2,016 | 1,960 | - | 25.0 | 50,445 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Mar 2024 | 2,051 | 53,279 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Mar 2024 | 22,386 | 24,346 | - | 2.1 | 47,906 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2024 | 114 | 58,763 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2024 | 20,986 | 58,877 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2024 | 1,400 | 28,263 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2024 | 3,433 | 55,330 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 26.30 per share. | 07 Mar 2024 | 10 | 1,960 | - | 26.3 | 263 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.24 per share. | 07 Mar 2024 | 3,423 | 1,970 | - | 25.2 | 86,404 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Mar 2024 | 3,433 | 5,393 | - | 2.1 | 7,347 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 07 Mar 2024 | 114 | 1,960 | - | 25 | 2,850 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Mar 2024 | 114 | 2,074 | - | 2.1 | 244 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 07 Mar 2024 | 22,386 | 1,960 | - | 25.0 | 559,688 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2024 | 8,030 | 101,510 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2024 | 945 | 15,324 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 24.50 per share. | 07 Mar 2024 | 8,975 | 3,251 | - | 24.5 | 219,888 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Mar 2024 | 8,975 | 12,226 | - | 2.1 | 19,207 | Common Stock |
| Habib Joseph Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2024 | 1,531 | 1,531 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 23 Feb 2024 | 511 | 3,251 | - | 19.5 | 9,965 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Feb 2024 | 511 | 3,014 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 23 Feb 2024 | 511 | 3,762 | - | 1.7 | 889 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 987 | 8,036 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 20 Feb 2024 | 3,489 | 6,740 | - | 1.7 | 6,071 | Common Stock |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 2,502 | 3,525 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 20.11 per share. | 20 Feb 2024 | 2,591 | 4,149 | - | 20.1 | 52,097 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 20.58 per share. | 20 Feb 2024 | 898 | 3,251 | - | 20.6 | 18,478 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 1,500 | 41,732 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Feb 2024 | 3,200 | 6,209 | - | 2.1 | 6,848 | Common Stock |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 500 | 10,894 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Feb 2024 | 1,400 | 3,009 | - | 1.7 | 2,436 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 500 | 9,088 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 1,200 | 34,908 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 17.45 per share. | 05 Feb 2024 | 4,600 | 1,609 | - | 17.4 | 80,249 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 900 | 13,308 | - | - | Stock Option (Right to Buy) | |
| P. Timothy Noyes | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2024 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Timothy Pigot | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 66,586 | 66,586 | - | - | Stock Option (Right to Buy) | |
| Marinus Verwijs | CHIEF TECHNOLOGY OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 66,586 | 66,586 | - | - | Stock Option (Right to Buy) | |
| T. Benjamin Dake | SEE REMARKS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 66,586 | 66,586 | - | - | Stock Options (Right to Buy) | |
| A. Eldridge George | SEE REMARKS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 66,586 | 66,586 | - | - | Stock Options (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 66,586 | 66,586 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 66,586 | 66,586 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 17 Jan 2024 | 4,000 | 3,251 | - | 19.5 | 78,000 | Common Stock |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 17 Jan 2024 | 4,000 | 7,251 | - | 1.7 | 6,960 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2024 | 4,000 | 6,027 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 19.57 per share. | 05 Jan 2024 | 2,474 | 1,609 | - | 19.6 | 48,421 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2024 | 900 | 14,208 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2024 | 1,500 | 43,232 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2024 | 500 | 11,394 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Jan 2024 | 1,400 | 3,009 | - | 1.7 | 2,436 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 18.67 per share. | 05 Jan 2024 | 2,126 | 4,083 | - | 18.7 | 39,695 | Common Stock |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2024 | 500 | 9,588 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2024 | 1,200 | 36,108 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Jan 2024 | 3,200 | 6,209 | - | 2.1 | 6,848 | Common Stock |
| Donald Santel J. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 2,889 | 2,889 | - | - | Stock Option (Right to Buy) | |
| Katabi Maha | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 3,519 | 3,519 | - | - | Stock Option (Right to Buy) | |
| S. David Grayzel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 3,186 | 3,186 | - | - | Stock Option (Right to Buy) | |
| J. Habib Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 2,964 | 2,964 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 24.50 per share. | 27 Dec 2023 | 125 | 3,251 | - | 24.5 | 3,063 | Common Stock |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2023 | 100 | 109,540 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 27 Dec 2023 | 125 | 3,376 | - | 2.1 | 268 | Common Stock |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2023 | 25 | 16,269 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 2,924 | 9,023 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 20 Dec 2023 | 4,000 | 7,251 | - | 1.7 | 6,960 | Common Stock |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 20 Dec 2023 | 4,000 | 3,251 | - | 19.5 | 78,000 | Common Stock |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 1,076 | 10,027 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 653 | 15,444 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 13 Dec 2023 | 2,103 | 5,354 | - | 1.7 | 3,659 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 13 Dec 2023 | 2,103 | 3,251 | - | 19.5 | 41,009 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 1,450 | 17,503 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 7,197 | 10,306 | - | - | Stock Option (Right to Buy) | |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 13 Dec 2023 | 9,897 | 13,148 | - | 1.7 | 17,221 | Common Stock |
| Gillies Hunter | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 2,700 | 12,744 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 13 Dec 2023 | 9,897 | 3,251 | - | 19.5 | 192,992 | Common Stock |
| Benjamin Dake T. | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2023 | 1,019 | 16,294 | - | - | Stock Option (Right to Buy) | |
| Benjamin Dake T. | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.11 per share. | 06 Dec 2023 | 10,283 | 1,291 | - | 16.1 | 165,628 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Dec 2023 | 2,411 | 3,702 | - | 1.7 | 4,195 | Common Stock |
| Benjamin Dake T. | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Dec 2023 | 7,872 | 11,574 | - | 2.1 | 16,846 | Common Stock |
| Dake T. Benjamin | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2023 | 905 | 906 | - | - | Stock Option (Right to Buy) | |
| T. Benjamin Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2023 | 6,853 | 123,346 | - | - | Stock Option (Right to Buy) | |
| Benjamin Dake T. | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2023 | 1,506 | 12,055 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Dec 2023 | 3,200 | 6,209 | - | 2.1 | 6,848 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 1,200 | 37,308 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 900 | 15,108 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 500 | 10,088 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 500 | 11,894 | - | - | Stock Option (Right to Buy) | |
| Niven Ralph | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Dec 2023 | 1,400 | 3,009 | - | 1.7 | 2,436 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 16.30 per share. | 05 Dec 2023 | 4,600 | 1,609 | - | 16.3 | 74,996 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 1,500 | 44,732 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 07 Aug 2023 | 2,412 | 3,703 | - | 1.7 | 4,197 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2023 | 6,853 | 150,756 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2023 | 1,018 | 20,368 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2023 | 1,507 | 18,082 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2023 | 905 | 4,528 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.25 per share. | 07 Aug 2023 | 541 | 1,291 | - | 16.2 | 8,789 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 15.48 per share. | 07 Aug 2023 | 9,742 | 1,832 | - | 15.5 | 150,792 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Aug 2023 | 7,871 | 11,574 | - | 2.1 | 16,844 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 28 Jul 2023 | 5,478 | 0 | - | 18 | 98,604 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jul 2023 | 5,478 | 383,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 28 Jul 2023 | 5,478 | 5,478 | - | 2.1 | 11,723 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 17 Jul 2023 | 4,522 | 4,522 | - | 2.1 | 9,677 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 4,522 | 388,859 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 18.11 per share. | 17 Jul 2023 | 4,522 | 0 | - | 18.1 | 81,896 | Common Stock |
| Habib J. Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jul 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Jul 2023 | 7,871 | 11,574 | - | 2.1 | 16,844 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2023 | 6,852 | 157,609 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2023 | 1,019 | 21,386 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2023 | 1,506 | 19,589 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2023 | 906 | 5,433 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.66 per share. | 06 Jul 2023 | 10,283 | 1,291 | - | 16.7 | 171,284 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Jul 2023 | 2,412 | 3,703 | - | 1.7 | 4,197 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 17.23 per share. | 05 Jul 2023 | 2,031 | 1,828 | - | 17.2 | 35,002 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Jul 2023 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Jul 2023 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2023 | 750 | 50,732 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2023 | 650 | 42,108 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2023 | 200 | 13,894 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2023 | 200 | 12,088 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2023 | 450 | 18,708 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 17.87 per share. | 05 Jul 2023 | 219 | 1,609 | - | 17.9 | 3,913 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 03 Jul 2023 | 10,000 | 0 | - | 18 | 180,000 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2023 | 10,000 | 393,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 03 Jul 2023 | 10,000 | 10,000 | - | 2.1 | 21,400 | Common Stock |
| Donald J. Santel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Mark T. Iwicki | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Allison Dorval | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Joshua Resnick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Maha Katabi | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| David S. Grayzel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.28 per share. | 06 Jun 2023 | 10,268 | 1,306 | - | 16.3 | 167,161 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Jun 2023 | 7,871 | 11,574 | - | 2.1 | 16,844 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Jun 2023 | 2,412 | 3,703 | - | 1.7 | 4,197 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2023 | 1,507 | 21,095 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2023 | 1,018 | 22,405 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 06 Jun 2023 | 15 | 1,291 | - | 17 | 255 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2023 | 6,853 | 164,461 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2023 | 905 | 6,339 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Jun 2023 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2023 | 750 | 51,482 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2023 | 650 | 42,758 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2023 | 200 | 14,094 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2023 | 200 | 12,288 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2023 | 450 | 19,158 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 16.26 per share. | 05 Jun 2023 | 2,250 | 1,609 | - | 16.3 | 36,576 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Jun 2023 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 19 May 2023 | 65 | 3,251 | - | 19.5 | 1,268 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2023 | 65 | 18,953 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 19 May 2023 | 65 | 3,316 | - | 1.7 | 113 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 17 May 2023 | 1,090 | 4,341 | - | 1.7 | 1,897 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 1,090 | 19,018 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.59 per share. | 17 May 2023 | 1,090 | 3,251 | - | 19.6 | 21,356 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 08 May 2023 | 2,413 | 3,704 | - | 1.7 | 4,199 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2023 | 6,853 | 171,314 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2023 | 1,018 | 23,423 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2023 | 1,507 | 22,602 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2023 | 906 | 7,244 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 22.74 per share. | 08 May 2023 | 1,599 | 1,291 | - | 22.7 | 36,355 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 21.62 per share. | 08 May 2023 | 8,685 | 2,890 | - | 21.6 | 187,805 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 08 May 2023 | 7,871 | 11,575 | - | 2.1 | 16,844 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 May 2023 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 May 2023 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 May 2023 | 750 | 52,232 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 May 2023 | 650 | 43,408 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 May 2023 | 200 | 14,294 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 May 2023 | 200 | 12,488 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 May 2023 | 450 | 19,608 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 21.63 per share. | 05 May 2023 | 205 | 1,609 | - | 21.6 | 4,435 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 20.79 per share. | 05 May 2023 | 2,045 | 1,814 | - | 20.8 | 42,522 | Common Stock |
| Marinus Verwijs | SENIOR VICE PRESIDENT, CMC | Sale of securities on an exchange or to another person at price $ 20.79 per share. | 03 May 2023 | 759 | 0 | - | 20.8 | 15,779 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 20.61 per share. | 01 May 2023 | 15,000 | 693 | - | 20.6 | 309,089 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2023 | 15,000 | 403,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 21.15 per share. | 01 May 2023 | 693 | 0 | - | 21.2 | 14,657 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 01 May 2023 | 15,000 | 15,693 | - | 2.1 | 32,100 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 21 Apr 2023 | 4,000 | 1,960 | - | 19.5 | 78,000 | Common Stock |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2023 | 4,000 | 20,108 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 21 Apr 2023 | 4,000 | 5,960 | - | 1.7 | 6,960 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Apr 2023 | 2,412 | 2,412 | - | 1.7 | 4,197 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Apr 2023 | 7,871 | 10,283 | - | 2.1 | 16,844 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 18.17 per share. | 06 Apr 2023 | 10,283 | 0 | - | 18.2 | 186,829 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2023 | 905 | 8,150 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2023 | 1,507 | 24,109 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2023 | 1,019 | 24,441 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2023 | 6,852 | 178,167 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Apr 2023 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2023 | 750 | 52,982 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2023 | 650 | 44,058 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2023 | 200 | 14,494 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2023 | 200 | 12,688 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2023 | 450 | 20,058 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 19.10 per share. | 05 Apr 2023 | 535 | 1,609 | - | 19.1 | 10,221 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 17.91 per share. | 05 Apr 2023 | 1,715 | 2,144 | - | 17.9 | 30,721 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Apr 2023 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 19.16 per share. | 03 Apr 2023 | 9,172 | 5,828 | - | 19.2 | 175,690 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2023 | 15,000 | 418,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 19.77 per share. | 03 Apr 2023 | 5,828 | 0 | - | 19.8 | 115,227 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 03 Apr 2023 | 15,000 | 15,000 | - | 2.1 | 32,100 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 139,067 | 139,067 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Mar 2023 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 750 | 53,732 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 650 | 44,708 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 200 | 14,694 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 200 | 12,888 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 450 | 20,508 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 24.93 per share. | 06 Mar 2023 | 45 | 1,609 | - | 24.9 | 1,122 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 23.73 per share. | 06 Mar 2023 | 2,205 | 1,654 | - | 23.7 | 52,318 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Mar 2023 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Mar 2023 | 2,412 | 2,412 | - | 1.7 | 4,197 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 6,852 | 185,019 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 1,018 | 25,460 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 1,506 | 25,616 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 906 | 9,055 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 24.50 per share. | 06 Mar 2023 | 215 | 0 | - | 24.5 | 5,267 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 23.71 per share. | 06 Mar 2023 | 10,067 | 215 | - | 23.7 | 238,687 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Mar 2023 | 7,870 | 10,282 | - | 2.1 | 16,842 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 22.71 per share. | 01 Mar 2023 | 5,962 | 9,038 | - | 22.7 | 135,380 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2023 | 15,000 | 433,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 25.67 per share. | 01 Mar 2023 | 1,050 | 0 | - | 25.7 | 26,954 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 24.69 per share. | 01 Mar 2023 | 5,316 | 1,050 | - | 24.7 | 131,240 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 23.81 per share. | 01 Mar 2023 | 2,672 | 6,366 | - | 23.8 | 63,623 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 01 Mar 2023 | 15,000 | 15,000 | - | 2.1 | 32,100 | Common Stock |
| George A. Eldridge | SEE REMARKS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2023 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Hunter Gillies | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2023 | 62,000 | 62,000 | - | - | Stock Option (Right to Buy) | |
| Marinus Verwijs | SENIOR VICE PRESIDENT, CMC | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2023 | 62,000 | 62,000 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 650 | 45,358 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 62,000 | 62,000 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 750 | 54,482 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 200 | 14,894 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 200 | 13,088 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 450 | 20,958 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 24.27 per share. | 06 Feb 2023 | 2,250 | 1,609 | - | 24.3 | 54,612 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Feb 2023 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Feb 2023 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Feb 2023 | 2,412 | 2,412 | - | 1.7 | 4,197 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 62,000 | 62,000 | - | - | Stock Options (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 6,853 | 191,871 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 1,019 | 26,478 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 1,507 | 27,122 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 905 | 9,961 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.02 per share. | 06 Feb 2023 | 1,426 | 0 | - | 25.0 | 35,679 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 24.52 per share. | 06 Feb 2023 | 8,858 | 1,426 | - | 24.5 | 217,203 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Feb 2023 | 7,872 | 10,284 | - | 2.1 | 16,846 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 15,000 | 448,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 23.05 per share. | 01 Feb 2023 | 4,495 | 0 | - | 23.1 | 103,611 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 22.52 per share. | 01 Feb 2023 | 10,505 | 4,495 | - | 22.5 | 236,586 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 01 Feb 2023 | 15,000 | 15,000 | - | 2.1 | 32,100 | Common Stock |
| Donald J. Santel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Donald J. Santel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2023 | 2,519 | 2,519 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Jan 2023 | 2,413 | 2,413 | - | 1.7 | 4,199 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2023 | 36,570 | 198,724 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2023 | 1,018 | 27,497 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2023 | 1,507 | 28,629 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2023 | 906 | 10,866 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 26.95 per share. | 06 Jan 2023 | 2,792 | 0 | - | 27.0 | 75,254 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.62 per share. | 06 Jan 2023 | 7,492 | 2,792 | - | 25.6 | 191,949 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Jan 2023 | 7,871 | 10,284 | - | 2.1 | 16,844 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Jan 2023 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 750 | 55,232 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 650 | 46,008 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 200 | 15,094 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 200 | 13,288 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 450 | 21,408 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 26.40 per share. | 05 Jan 2023 | 2,250 | 1,609 | - | 26.4 | 59,405 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Jan 2023 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 28.78 per share. | 03 Jan 2023 | 791 | 15 | - | 28.8 | 22,762 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 15,000 | 463,381 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 29.80 per share. | 03 Jan 2023 | 15 | 0 | - | 29.8 | 447 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 26.80 per share. | 03 Jan 2023 | 11,927 | 3,073 | - | 26.8 | 319,611 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 27.90 per share. | 03 Jan 2023 | 2,267 | 806 | - | 27.9 | 63,256 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 03 Jan 2023 | 15,000 | 15,000 | - | 2.1 | 32,100 | Common Stock |
| Maha Katabi | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 2,627 | 2,627 | - | - | Stock Option (Right to Buy) | |
| David S. Grayzel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 2,654 | 2,654 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 30.26 per share. | 12 Dec 2022 | 907 | 0 | - | 30.3 | 27,443 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 28.83 per share. | 12 Dec 2022 | 1,132 | 907 | - | 28.8 | 32,632 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.80 per share. | 12 Dec 2022 | 20 | 2,039 | - | 25.8 | 516 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 12 Dec 2022 | 2,059 | 2,059 | - | 2.1 | 4,406 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2022 | 2,059 | 205,577 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 24.23 per share. | 09 Dec 2022 | 3,386 | 2,543 | - | 24.2 | 82,055 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 09 Dec 2022 | 3,969 | 5,929 | - | 2.1 | 8,494 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2022 | 7,094 | 29,663 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2022 | 2,906 | 79,863 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2022 | 3,969 | 36,757 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 30.04 per share. | 09 Dec 2022 | 10,000 | 1,960 | - | 30.0 | 300,428 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 09 Dec 2022 | 10,000 | 11,960 | - | 2.1 | 21,400 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.23 per share. | 09 Dec 2022 | 583 | 1,960 | - | 25.2 | 14,711 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2022 | 10,000 | 208,030 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 08 Dec 2022 | 10,000 | 10,000 | - | 2.1 | 21,400 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.94 per share. | 08 Dec 2022 | 928 | 9,072 | - | 20.9 | 19,435 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 21.63 per share. | 08 Dec 2022 | 2,695 | 6,377 | - | 21.6 | 58,302 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 22.56 per share. | 08 Dec 2022 | 3,199 | 3,178 | - | 22.6 | 72,178 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 24.08 per share. | 08 Dec 2022 | 3,178 | 0 | - | 24.1 | 76,533 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 08 Dec 2022 | 394 | 394 | - | 2.1 | 843 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2022 | 394 | 207,636 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 25.03 per share. | 08 Dec 2022 | 394 | 0 | - | 25.0 | 9,861 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2022 | 11,637 | 84,656 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2022 | 10,124 | 40,726 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2022 | 1,887 | 82,769 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 24.20 per share. | 07 Dec 2022 | 11,031 | 1,960 | - | 24.2 | 266,974 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.60 per share. | 07 Dec 2022 | 20 | 12,991 | - | 20.6 | 412 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.12 per share. | 07 Dec 2022 | 960 | 13,011 | - | 20.1 | 19,314 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Dec 2022 | 12,011 | 13,971 | - | 2.1 | 25,704 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.40 per share. | 07 Dec 2022 | 4,558 | 1,960 | - | 20.4 | 92,993 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 19.37 per share. | 07 Dec 2022 | 7,079 | 6,518 | - | 19.4 | 137,090 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Dec 2022 | 11,637 | 13,597 | - | 2.1 | 24,903 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2022 | 1,507 | 30,136 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 18.29 per share. | 06 Dec 2022 | 615 | 0 | - | 18.3 | 11,250 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 06 Dec 2022 | 36,115 | 615 | - | 17.8 | 642,861 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.90 per share. | 06 Dec 2022 | 1,259 | 36,730 | - | 16.9 | 21,275 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 15.61 per share. | 06 Dec 2022 | 2,011 | 37,989 | - | 15.6 | 31,386 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Dec 2022 | 37,588 | 40,000 | - | 2.1 | 80,438 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 06 Dec 2022 | 2,412 | 2,412 | - | 1.7 | 4,197 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2022 | 36,570 | 218,030 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2022 | 1,018 | 28,515 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2022 | 905 | 11,772 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 200 | 13,488 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 750 | 55,982 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 650 | 46,658 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 200 | 15,294 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 450 | 21,858 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 17.38 per share. | 05 Dec 2022 | 2,250 | 1,609 | - | 17.4 | 39,114 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 05 Dec 2022 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 05 Dec 2022 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 01 Dec 2022 | 15,000 | 0 | - | 18 | 270,000 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 01 Dec 2022 | 15,000 | 15,000 | - | 2.1 | 32,100 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2022 | 15,000 | 478,381 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 19.06 per share. | 30 Nov 2022 | 85 | 1,960 | - | 19.1 | 1,620 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 30 Nov 2022 | 85 | 2,045 | - | 2.1 | 182 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2022 | 85 | 96,293 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2022 | 1,261 | 96,378 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 19.07 per share. | 23 Nov 2022 | 1,261 | 1,960 | - | 19.1 | 24,048 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 23 Nov 2022 | 1,261 | 3,221 | - | 2.1 | 2,699 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 18 Nov 2022 | 861 | 2,821 | - | 2.1 | 1,843 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 19.45 per share. | 18 Nov 2022 | 780 | 2,041 | - | 19.5 | 15,174 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2022 | 174 | 97,639 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2022 | 2 | 97,813 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2022 | 861 | 97,815 | - | - | Stock Option (Right to Buy) | |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 19.01 per share. | 18 Nov 2022 | 174 | 1,960 | - | 19.0 | 3,308 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 18 Nov 2022 | 174 | 2,134 | - | 2.1 | 372 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 18 Nov 2022 | 2 | 1,960 | - | 19 | 38 | Common Stock |
| George A. Eldridge | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.00 per share. | 18 Nov 2022 | 2 | 1,962 | - | 2 | 4 | Common Stock |
| George A. Eldridge | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.14 per share. | 18 Nov 2022 | 81 | 1,960 | - | 20.1 | 1,631 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 17.91 per share. | 09 Nov 2022 | 14,000 | 0 | - | 17.9 | 250,677 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Nov 2022 | 6,198 | 254,600 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Nov 2022 | 1,800 | 260,798 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Nov 2022 | 14,000 | 262,598 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 22.20 per share. | 09 Nov 2022 | 121 | 0 | - | 22.2 | 2,686 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 21.41 per share. | 09 Nov 2022 | 1,625 | 121 | - | 21.4 | 34,796 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.38 per share. | 09 Nov 2022 | 4,452 | 1,746 | - | 20.4 | 90,754 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 09 Nov 2022 | 6,198 | 6,198 | - | 2.1 | 13,264 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.10 per share. | 09 Nov 2022 | 1,800 | 0 | - | 20.1 | 36,172 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 09 Nov 2022 | 1,800 | 1,800 | - | 2.1 | 3,852 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 09 Nov 2022 | 14,000 | 14,000 | - | 2.1 | 29,960 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 450 | 22,308 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 19.82 per share. | 07 Nov 2022 | 1,430 | 1,824 | - | 19.8 | 28,347 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 07 Nov 2022 | 155 | 3,254 | - | 18.0 | 2,794 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 17.09 per share. | 07 Nov 2022 | 450 | 3,409 | - | 17.1 | 7,691 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Nov 2022 | 1,600 | 3,859 | - | 2.1 | 3,424 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 07 Nov 2022 | 650 | 2,259 | - | 1.7 | 1,131 | Common Stock |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 750 | 56,732 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 650 | 47,308 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 200 | 15,494 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 200 | 13,688 | - | - | Stock Option (Right to Buy) | |
| Ralph Niven | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 20.29 per share. | 07 Nov 2022 | 215 | 1,609 | - | 20.3 | 4,363 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 18.58 per share. | 07 Nov 2022 | 3,359 | 3,146 | - | 18.6 | 62,399 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Nov 2022 | 15,214 | 17,627 | - | 2.1 | 32,558 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.74 per share. | 07 Nov 2022 | 2,413 | 2,413 | - | 1.7 | 4,199 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 1,019 | 29,533 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 14,195 | 284,971 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 8,373 | 276,598 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 17.79 per share. | 07 Nov 2022 | 11,122 | 6,505 | - | 17.8 | 197,819 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 905 | 12,677 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2022 | 1,507 | 31,643 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 18.09 per share. | 07 Nov 2022 | 8,373 | 0 | - | 18.1 | 151,458 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 07 Nov 2022 | 8,373 | 8,373 | - | 2.1 | 17,918 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.24 per share. | 07 Nov 2022 | 1,660 | 0 | - | 20.2 | 33,594 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 19.57 per share. | 07 Nov 2022 | 1,486 | 1,660 | - | 19.6 | 29,081 | Common Stock |
| Marinus Verwijs | SENIOR VICE PRESIDENT, CMC | Sale of securities on an exchange or to another person at price $ 18.89 per share. | 02 Nov 2022 | 1,130 | 0 | - | 18.9 | 21,346 | Common Stock |
| Timothy P. Noyes | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 01 Nov 2022 | 1,038 | 0 | - | 19.5 | 20,241 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 18 Oct 2022 | 5,705 | 5,705 | - | 2.1 | 12,209 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Oct 2022 | 5,705 | 299,166 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 21.08 per share. | 18 Oct 2022 | 5,705 | 0 | - | 21.1 | 120,287 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.16 per share. | 14 Oct 2022 | 4,185 | 0 | - | 20.2 | 84,380 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 14 Oct 2022 | 4,185 | 4,185 | - | 2.1 | 8,956 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 14 Oct 2022 | 110 | 110 | - | 2.1 | 235 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 14 Oct 2022 | 110 | 0 | - | 20.1 | 2,206 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2022 | 4,185 | 304,871 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2022 | 110 | 309,056 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.74 per share. | 10 Oct 2022 | 3,524 | 1,430 | - | 16.7 | 58,992 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Oct 2022 | 4,954 | 309,166 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 17.27 per share. | 10 Oct 2022 | 1,430 | 0 | - | 17.3 | 24,689 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 10 Oct 2022 | 4,954 | 4,954 | - | 2.1 | 10,602 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.41 per share. | 06 Oct 2022 | 1,757 | 0 | - | 16.4 | 28,828 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2022 | 10,520 | 314,120 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2022 | 4,281 | 324,640 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2022 | 6,348 | 30,552 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2022 | 1,506 | 33,150 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2022 | 905 | 13,583 | - | - | Stock Option (Right to Buy) | |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 15.93 per share. | 06 Oct 2022 | 8,763 | 1,757 | - | 15.9 | 139,631 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Oct 2022 | 10,520 | 10,520 | - | 2.1 | 22,513 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 17.31 per share. | 06 Oct 2022 | 948 | 0 | - | 17.3 | 16,411 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 16.54 per share. | 06 Oct 2022 | 882 | 948 | - | 16.5 | 14,589 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Sale of securities on an exchange or to another person at price $ 15.64 per share. | 06 Oct 2022 | 11,210 | 1,830 | - | 15.6 | 175,345 | Common Stock |
| Benjamin T. Dake | SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.14 per share. | 06 Oct 2022 | 10,629 | 13,040 | - | 2.1 | 22,746 | Common Stock |